Ese biomarker nshya yamaraso ishobora gufasha guhanura ibyago bya Alzheimer?

Ubushakashatsi bushya bwerekana ko astrocytes, ubwoko bwingirangingo zubwonko, ari ngombwa muguhuza amyloide-β nintambwe yambere ya tau patologiya.Karyna Bartashevich / Ububiko

• Astrocytes zifatika, ubwoko bwingirabuzimafatizo zubwonko, zishobora gufasha abahanga gusobanukirwa impamvu abantu bamwe bafite ubwenge buzira umuze hamwe na amyloide-β babitse mubwonko bwabo badakura ibindi bimenyetso bya Alzheimer, nka proteine ​​za tau.
• Ubushakashatsi bwakozwe n'abantu barenga 1.000 bwarebaga biomarkers maze busanga amyloide-β ifitanye isano gusa no kwiyongera kwa tau ku bantu bafite ibimenyetso byerekana reaction ya astrocyte.
• Ubushakashatsi bwerekana ko astrocytes ari ingenzi mu guhuza amyloide-β nintambwe yambere ya tau patologiya, ishobora guhindura uburyo dusobanura indwara ya Alzheimer kare.

Ikusanyirizo rya plaque amyloide hamwe na tau proteine ​​zifunze mu bwonko kuva kera byafashwe nkimpamvu nyamukuru iteraIndwara ya Alzheimer (AD).

Iterambere ryibiyobyabwenge ryakunze kwibanda ku kwibasira amyloide na tau, birengagiza uruhare rushoboka rwibindi bikorwa byubwonko, nka sisitemu ya neuroimmune.

Ubu, ubushakashatsi bushya bwakozwe n’ishuri ry’ubuvuzi rya kaminuza ya Pittsburgh bwerekana ko astrocytes, ari zo ngirabuzimafatizo zo mu bwonko zifite inyenyeri, zigira uruhare runini mu kumenya iterambere rya Alzheimer.

Astrocytes Yizewe Inkomokoni byinshi mu bwonko.Kuruhande rwizindi ngirabuzimafatizo, ubwonko butuye ubwonko bwubwonko, astrocytes ifasha neuron ibaha intungamubiri, ogisijeni, no kwirinda indwara ziterwa na virusi.

Mbere uruhare rwa astrocytes mu itumanaho rya neuronal rwari rwarirengagijwe kuva ingirabuzimafatizo zidakora amashanyarazi nka neuron.Ariko ubushakashatsi bwakozwe na kaminuza ya Pittsburg bwamaganye iki gitekerezo kandi bugaragaza uruhare rukomeye rwa astrocytes mu buzima bw’ubwonko n'indwara.

Ibyavuye mu bushakashatsi biherutse gutangazwa muriUbuvuzi Kamere Yizewe Inkomoko.

Ubushakashatsi bwakozwe mbere yerekana ko ihungabana ryimikorere yubwonko burenze umutwaro wa amyloide, nko kwiyongera kwubwonko bwubwonko, bishobora kugira uruhare runini mugutangiza uruhererekane rw’indwara z’urupfu rwa neuronal bigatuma igabanuka ryubwenge bwihuse muri Alzheimer.

Muri ubu bushakashatsi bushya, abashakashatsi bakoze ubushakashatsi ku maraso ku bitabiriye 1.000 baturutse mu bushakashatsi butatu butandukanye burimo abantu bakuze bafite ubuzima bwiza bakuze bafite amyloide.

Basesenguye icyitegererezo cyamaraso kugirango basuzume biomarkers ya reaction ya astrocyte, cyane cyane proteine ​​glial fibrillary acide (GFAP), ifatanije na tau ya patologi.

Abashakashatsi bavumbuye ko abafite umutwaro wa amyloide hamwe n'ibimenyetso by'amaraso byerekana ko ibikorwa bya astrocyte bidasanzwe cyangwa reaction bishobora kuba byanduye Alzheimer mu bihe biri imbere.