Ese amaraso mashya yamaraso afasha guhanura Alzheimer?

Inyigisho nshya yerekana ko astrocytes, ubwoko bwubwonko bwubwonko, ni ngombwa muguhuza Amyloid-β hamwe nibyiciro byambere bya Tau Patologiya. Karyna Bartathevich / Ububiko

• Astrocytites, ubwoko bw'ubwonko bw'ubwonko, bushobora gufasha abahanga kumva impamvu abantu bamwe bafite ubuzima bwiza na amyloide-β Proteeines.
• Ubushakashatsi hamwe n'abitabiriye 1.000 bwarebye abarinzi basanga Amyloid-β yahujwe gusa n'inzego zongerewe gusa muri Tau ku giti cye mu bantu bafite ibimenyetso by'ikimenyetso.
• Ibitekerezo byerekana ko astrocytes ari ngombwa muguhuza Amyloid-β hamwe nibyiciro byambere bya Tau Pathologiya, bishobora guhindura uko dusobanura indwara ya Alzheimer.

Kwegeranya icyapa cya amyloid hamwe na taus poroteine ​​za Tau muri ubwonko bumaze igihe kinini ifatwa nkimpamvu nyamukuru yaIndwara ya Alzheimer (AD).

Gutezimbere ibiyobyabwenge byakunze kwibanda ku kwibasira amyloid na tau, kwirengagiza uruhare rushobora kuba izindi nzira, nka sisitemu ya neuroimmune.

Noneho, ubushakashatsi bushya bwakozwe na kaminuza ya Santisburgh yo mu Buvuzi bwerekana ko astrocyaytes, ari ingirabuzimafatizo z'ubworozi bw'inyenyeri, rugira uruhare rukomeye mu kugena iterambere rya Alzheimer.

Inkomoko ya Astrocytessni byinshi muri tissue yo mu bwonko. Kuruhande rwibindi selile zikaze, selile zubwonko zidatungiye mu bwonko, astrocytes zishyigikira neuron ubaha intungamubiri, ogisijeni, no kurinda indwara.

Mbere uruhare rwa astrocytes mu itumanaho rya Neuronal rwari ryirengagijwe kuva selile za kall zidakora amashanyarazi nka neurons. Ariko kaminuza ya Pictsburg ivuga ko iki kibazo cyo kwiga iki gitekerezo kandi kikatangari ku ruhare ku ruhare rukomeye rwa astrocytes mu buzima bw'ubwonko n'indwara.

Ibisubizo biherutse gusohokaIbidukikije Inkomoko.

Ubushakashatsi bwabanje bwerekana ko guhungabana mu gutunganya ibintu byo mu bwonko hakurya ya Amyloid, nko kwiyongera mu bwonko rukomeye mu gutangiza uru rutonde rwa Neurologiya rw'urupfu rwa Neuronal rutera kwiyongera kwa Ragn muri Alzheimer.

Muri ubu bushakashatsi bushya, abashakashatsi bakoze ibizamini bya amaraso ku manota 1.000 bitabiriye ubushakashatsi butatu burimo abantu bakuru bakuze bafite ubuzima bwiza kandi badafite Amyloide.

Basesenguye amaraso kugirango basuzume abaxikers ba atrocyte bahura nabyo, Protebric Protein (Gfap), hamwe no kubahiriza Tau Patologiya.

Abashakashatsi bavumbuye ko abafite amyloid bombi bonyine na maraso byerekana ko ibikorwa bidasanzwe bya astrocyte cyangwa bagenda batera imbere batezimbere ibimenyetso bya Alzheimetike.